A ballot measure to require deep setbacks from oil and gas operations in Colorado picked up a long list of opponents Wednesday.

Proposition 112 would require industry operations to be at least 2,500 feet from schools, homes and businesses, instead of the current 1,00o-foot setback for schools and hospitals and 500 feet from homes.

A nearly half-mile setback has been called virtual ban based on where deposits are located, say those who have opposed the measure backed by Colorado Rising. That list includes Democratic gubernatorial nominee Jared Polis. Republican nominee Walker Stapleton, an unabashed supporter of the oil and gas association, also opposes the proposition.

A separate, somewhat competing measure, Initiative 108, seeks to compensate those who lose value in the land because of regulations on such this as blocking mineral rights.

RELATED: Initiative 108: A record 209K petition signatures turned in

Thirty-one business associations and 42 elected officials added their name to the opposition Wednesday.

“The intent of this proposal is to in-effect ban almost all oil and gas production in Colorado,” Kelly Brough, president and CEO of the Denver Metro Chamber of Commerce, said in a statement. “But Colorado is a model for the country on how we can produce energy and protect our people and our environment. Proposition 112 goes too far and hurts our economy, hitting Colorado’s rural communities the hardest.”

Loren Furman, senior vice president of state and federal relations for the Colorado Association of Commerce and Industry, said studies she’s seen indicate three-quarters of the jobs lost because of restrictions on oil and gas development would be outside the industry, because of its broader support for the state economy.

“That is why you are seeing the business community working so hard to defeat this measure and to convince our fellow Coloradans to vote no on 112,” said Furman, who also is a board member for Vital Colorado, the business coalition supporting the industry.

Tony Gagliardi, state director of the National Federation of Independent Business (NFIB), fears the ripple effect could “literally trigger a recession in Colorado.”

“It doesn’t just ban drilling near residential areas – it also bans drilling in rural and sparsely populated areas, too.” he stated.

Here is a list of associations that officially opposed the measure this week:

Here is a list of officeholders who oppose it: